In trachoma, the infection triggers a poorly understood inflammatory response, which leads to conjunctival scarring and blinding complications. We are studying the way that the human immune system reacts to chlamydial infection in order to define biomarkers for progressive disease and to identify potential therapeutic targets for progressive scarring. We have conducted large scale cohort studies in Tanzania and Ethiopia that have regularly assessed people for disease and infection and corelated this with a number of immunological responses.
DjinniChip: Evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas
Tamsyn R Derrick, Natalia Sandetskaya, Harry Pickering, Andreas Kölsch, Athumani Ramadhani, Elias Mafuru, Patrick Massae, Aiweda Malisa, Tara Mtuy, Matthew J Burton, Martin J Holland, Dirk Kuhlmeier
Parasites & Vectors, 2020, In Press
The conjunctival transcriptome in Ethiopians after trichiasis surgery: associations with the development of eyelid contour abnormalities and the effect of oral doxycycline treatment
Tamsyn Derrick, Esmael Habtamu, Zerihun Tadesse, E. Kelly Callahan, Abebaw Worku, Bizuayehu Gashaw, David Macleod, David C.W. Mabey, Martin J. Holland, Matthew J Burton
Wellcome Open Research, 2019, 4:130
Progression of scarring trachoma in Tanzanian children: a four-year cohort study
A.M.Ramadhani, T.Derrick, D.Macleod, P.Massae, E.Mafuru, A.Malisa, K.Mbuya, C.h.Roberts, W.Makupa, T.Mtuy, R.L.Bailey, D.C.W.Mabey, M.J.Holland and M.J.Burton
PLOS Neglected Tropical Diseases, 2019, 13(8):e0007638
Ocular Immune Responses, Chlamydia trachomatis infection and Clinical Signs of Trachoma Before and After Azithromycin Mass Drug Administration in a Treatment Naïve Trachoma-Endemic Tanzanian Community
A.M.Ramadhani, T.Derrick, D.Macleod, P.Massae, A.Malisa, K.Mbuya, T.Mtuy, W.Makupa, C.Roberts, R.L.Bailey, D.C.W.Mabey, M.J.Holland and Matthew J. Burton
PLOS Neglected Tropical Diseases, 2019, 13(7):e0007559
Evaluation of a Chlamydia trachomatis specific, commercial, real-time PCR for use with ocular swabs
H.Pickering, M.J.Holland, A. R.Last, M.J.Burton and S.E.Burr
Parasites & Vectors, 2018, 11:102
Clinical signs of trachoma are prevalent among Solomon Islanders who have no persistent markers of prior infection with Chlamydia trachomatis.
R.Butcher, O.Sokana, K.Jack, L.Sui, C.Russell, A.Last, D.L.Martin, M.J.Burton, A.W.Solomon, D.C.W.Mabey, C.h.Roberts
Wellcome Open Research, 2018, 3:14
Immunofibrogenic Gene Expression Patterns in Tanzanian Children with Ocular Chlamydia trachomatis Infection, Active Trachoma and Scarring: Baseline Results of a Four-Year Longitudinal Study
A.Ramadhani, T.Derrick, D.Macleod, P.Massae, T.Mtuy, D.Jeffries, C.h.Roberts, R.L.Bailey, D.W.C.Mabey, M.J.Holland, M.J.Burton
Frontiers in Cellular and Infection Microbiology, 2017, 7:406
miRNAs that associate with conjunctival inflammation and ocular Chlamydia trachomatis infection do not predict progressive disease.
T.Derrick, A.Ramadhani, K.Mtengai, P.Massae, M.J.Burton and M.J.Holland
Pathogens and Disease, 2017, 72(2):ftx016
The relationship between Active Trachoma and ocular Chlamydia trachomatis infection before and after mass antibiotic treatment
A.Ramadhani, T.Derrick, D.Macleod, M.J.Holland and M.J.Burton
PLOS Neglected Tropical Diseases, 2016, 10 (10):e0005080
Fibroblasts profiling in scarring trachoma identifies IL6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop
Z.Kechagia, D.Ezra, M.J.Burton and M.Bailly
Scientific Reports, 2016, 6:28261
Increased epithelial expression of CTGF and S100A7 with elevated subepithelial expression of IL-1β in trachomatous trichiasis.
T.Derrick P.Luthert, H.Jama, V.H.Hu, P.Massae, D.Essex, M.J.Holland and M.J.Burton
PLOS Neglected Tropical Diseases, 2016, 10(6):e0004752
Immunohistochemical analysis of scarring trachoma indicates infiltration by Natural Killer and undefined CD45 negative cells.
V.H.Hu, P.Luthert, T.Derrick, J.Pullin, H.A.Weiss, P.Massae, T.Mtuy, W.Makupa, D.Essex, D.C.W.Mabey, R.L.Bailey, M.J.Holland and M.J.Burton
PLOS Neglected Tropical Diseases, 2016, 10(5):e0004734
Pathogenesis of Progressive Scarring Trachoma in Ethiopia and Tanzania and its Implications for Disease Control: Two Cohort Studies
M.J.Burton, S.N.Rajak, V.H.Hu, A.Ramadhani, E.Habtamu, P.Massae, Z.Tadesse, K.Callahan, P.M.Emerson, P.T.Khaw, D.Jeffries, D.C.W.Mabey, R.L.Bailey, H.A.Weiss and M.J.Holland
PLOS Neglected Tropical Diseases, 2015; 13;9(5):e0003763.
Estimating the future impact of a multi-pronged intervention strategy on the ocular disease sequelae caused by trachoma: a modelling study
M.Gambhir, N.C.Grassly, M.J.Burton, A.W.Solomon, H.R.Taylor, D.C.Mabey, I.M.Blake and, M.G.Basáñez
Ophthalmic Epidemiology, 2015; 22(6): 394-402
H.R.Taylor, M.J.Burton, D.Haddad, S.K.West and H.Wright
Lancet, 2014; 384(9960):2142-52
Trachoma: protective and pathogenic ocular immune responses to Chlamydia trachomatis
V.H.Hu, M.J.Holland and M.J.Burton
PLOS Neglected Tropical Diseases, 2013; 7(3):e2020